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Cofactor-Dependent Enzymatic Throughput Metabolic flux is ultimately executed through enzyme systems whose catalytic activity depends on micronutrient cofactors

As a consequence, the main mitochondrial proteome (~1500 proteins) is encoded by the nucleus, translated in the cytosol and imported into the mitochondria through specific translocator complexes (TIM and TOM) of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively