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Furthermore, the anti-fatigue effects of garlic polysaccharides are associated with their activation of the AMPK/PGC-1 pathway, reduction of oxidative stress, and regulation of gut microbiota 9

Thus, studies suggest that PQQ may be beneficial in insulin resistance and type 2 diabetes ( in vivo and in vitro , regulated by the NLRP3 inflammasome ( PQQ showed protective effects on lipotoxicity and inflammation caused by maternal obesity, and intervention on the risk of NAFLD (Zhou et al., 2021)

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