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This measured progression contrasts sharply with starting at standard doses, which can trigger nausea, vomiting, or appetite loss so severe that patients discontinue treatment

Studies in intestinal anastomosis healing, fistula research, and gastric protection models have all incorporated the combination as a multi-mechanism research tool

However, the side effects can be challenging

Eating too quickly or consuming large volumes at once increases nausea risk, even with reduced appetite

"They [the TGA] need to differentiate between the pharmacist that's making a single product off a single script because the doctor needs it, the patient needs it, and it's unavailable and these few cowboys out there that are bulk manufacturing, because there's a very big difference." Several compounding pharmacists the ABC has spoken to have argued producing off-brand weight loss drugs is helping patients access crucial medication they couldn't get otherwise