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In the medulla, an elevated UA concentration results in the deposition of urate precipitates and the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome

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Our newest blog breaks down whats actually happening during a plateau and why this phase is more common (and necessary) than you think

Various studies have now shown that GLP-1 and GLP-1RA drugs directly promote M2 phase while inhibiting M1 phase, this ties back to the reductions in TNF-a and IL-6 mentioned earlier, along with various other inflammatory cytokines

Leptin is an effective treatment for hypothalamic amenorrhea