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Kong X, Liu H, He X, Sun Y, Ge W

Oxidative gene reprogramming ERRs activate hundreds of target genes: mitochondrial biogenesis (NRF1, TFAM), oxidative phosphorylation (complex I, II, III, IV, V subunits), fatty acid beta-oxidation (CPT1B, MCAD, LCAD), Krebs cycle (IDH3, SDHA), type I fiber specification (myoglobin, Myh7, slow troponins), angiogenesis (VEGF-A)

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Since both drugs influence gastrointestinal function, starting with lower doses and gradual titration is generally advised

Spontaneous reporting may be the best way to find rare AEs, and real-world evidence of GLP-1RA-associated tumor risk is currently limited