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BBR dose-dependently inhibited IgE reduction in a non-cytotoxic manner (nearly 100% at 5 g/mL) and at 5 g/mL, inhibited X box binding protein 1 (XBP1), B-lymphocyte-induced maturation protein 1 (BLIMP1), and STAT6 suppression, and reduced mitochondrial oxidation rate of IgE-producing plasma cells in vitro (Fig

However, these findings cannot be extrapolated to transdermal delivery without specific evidence demonstrating equivalent bioavailability and pharmacokinetics

I am also a fan of different types of probiotics like soil-based probiotics (SBO) to further support rich bacterial diversity

doi: 10.1016/j.diabres.2016.08.004 42 MocarskiMYeawJDivinoVDeKovenMGuerreroGLangerJet al