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In preclinical studies of cancer cell lines and tumor xenografts, auranofin exhibits remarkable sensitivity across various forms of drug-resistant cancer cells, including ovarian cancer with a cisplatin-resistant phenotype [235]

The review found that oral and topical formulations demonstrate significant but variable melanin reduction with minimal side effects, while intravenous glutathione carries serious safety concerns including anaphylaxis and hepatotoxicity

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Glutathione and skin whitening: What is the relationship