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Fatigue and lethargy Clinical trials recorded fatigue as an occasional adverse event

Oncotarget 8 , 1552015538 (2017)

Behavioral testing (open field, social interaction, tail flick nociception) was conducted between postnatal days 3040, followed by biochemical analyses in cerebral cortex, hippocampus, striatum, and cerebellum

The maintenance frequency approach represents hybrid strategy where initial intensive treatment (daily application for 3-6 months) establishes improvements, then reduces to maintenance schedule (2-3 times weekly or every other day) rather than complete discontinuation

At Neighborhood Medical Center, Dr