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While GLP-1 medications have a low intrinsic risk of hypoglycaemia when used alone, this risk increases when combined with insulin or sulfonylureas, which may require dose adjustment of these other medications

Carnitine pool in the muscle and endurance The main limitation of oral supplementation is solved only by increasing the concentration of carnitine in the muscle itself and this is difficult

Improved adherence through easier administration could address one of the core arguments that led to coverage removal

Trulicity FDA Approval History , (Jan 28, 2021)

doi:10.1038/s41430-018-0348-y [30] Vondra K, Vrbikova J, Dvorakova K