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In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate
After its synthesis, GSH is delivered to some intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Forman et al., 2009)
The HF diet group exhibited less exploration of both novel and familiar objects compared to the control group, suggesting a general reduction in exploratory behavior in an unfamiliar environment
Une bonne et efficace coordination de ces systmes est cruciale pour viter une carence en glutathion et garantir qu'une quantit suffisante de glutathion actif soit disponible
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