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Other common gastrointestinal side effects include: Diarrhoea loose or frequent bowel movements affecting 20-30% of patients Constipation paradoxically, some patients experience reduced bowel frequency Abdominal pain or discomfort cramping or generalised abdominal discomfort Dyspepsia indigestion, bloating, or upper abdominal fullness Decreased appetite whilst this is part of the therapeutic effect, it can feel uncomfortable Beyond gastrointestinal symptoms, patients may experience other effects that contribute to feeling unwell

A patient in the 24% bracket using an HSA for semaglutide injection at $189/mo (or $149/mo on the 6-month plan) saves approximately $36 monthly ($432 annually) compared to after-tax payment

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Most clinicians use a pragmatic approach: the patient takes the last semaglutide injection on its normal schedule, then starts tirzepatide 2.5 mg on the following week's injection date

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