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Additionally, carnitine palmitoyltransferase 1A (CPT1A), identified as a pivotal rate-limiting enzyme in fatty acid oxidation through metabolomic, transcriptomic analyses, lung epithelial-specific CPT1A knockout mouse models, and clinical studies, synergizes with l-carnitine from tumor-associated macrophages to promote ferroptosis resistance and CD8 + T cell inactivation in lung cancer

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A variety of nutritional and botanical compounds have been shown to support glutathione recycling, including the following: N-acetyl-cysteine, which quickly metabolizes into intracellular glutathione