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People with treatment-resistant hypertension, especially those with co-existing diabetes, obesity, heart failure (HF), or chronic kidney disease (CKD) may particularly benefit from SGLT2-i and GLP-1RA
Patients with pre-existing gastrointestinal conditions, including GERD, peptic ulcer disease, or gastroparesis, should have closer monitoring during GLP-1 initiation and dose escalation
It is primarily accessible through compounded forms
Retatrutide reduces thirst perception while GI symptoms can cause fluid loss
Health Canada spokesperson Mark Johnson says evaluating generic semaglutide drugs is more complex than many other medication approvals, because the original product was developed using biological processes while generic versions can be made by simpler chemical means
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