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Unfortunately, no one yet knows
Medvidovic-Grubisic et al., 2017), stroke (Vukojevic et al., 2020), and spinal cord injury (Perovic et al., 2019))
This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice
Journal of Endocrinology, 204
In addition to blood sugar control, this hormone can also help reduce hunger cues in the brain and decrease appetite overall
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