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The FDA Category 2 Framework and the July 2026 PCAC Meeting In 2023, the FDA created a list of 19 peptides classified as Category 2: substances that do not currently fit the five legal compounding categories but have enough clinical interest and accumulated safety data to warrant regulatory review

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Machine-learning-guided directed evolution for protein engineering

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Dietary changes are high yield, with about 50% of patients finding relief from gastrointestinal symptoms after adjusting intake, which highlights sugar alcohols and fermentable carbohydrates as frequent triggers

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10.1016/j.jff.2023.105645 39 MatusheskiN.JefferyE

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