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doi:10.1093/ecam/nem136
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In the liver, it binds to heavy metals, environmental toxins, and metabolic waste products, making them water-soluble so they can be safely excreted through bile and urine
These breakdown products also activate neuro-inflammatory pathways, particularly the Toll-Like receptor 4 (TLR-4) activated NFB pathway ( These intricate cascades eventuate in the disruption of the bloodbrain barrier, microcirculatory dysfunction, and the manifestation of cerebral edema
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