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This happens due to temporary dilatation of blood vessels and usually fades quickly
This is analogous to the evidence pathway followed for liraglutide (LEADER trial, NEJM 2016) and semaglutide (SUSTAIN-6 trial, NEJM 2016), which established cardiovascular benefit for those agents only after large, long-term CVOTs reported [6] The heart rate increase warrants ongoing surveillance, particularly in patients with pre-existing cardiac conditions Phase 3 trials are currently underway (see ClinicalTrials.gov and the EU Clinical Trials Information System, CTIS, for registered studies)
Other common side effects include anxiety, depression, fast pulse (increase of 2.7 beats/min average), skin rash, and nervousness
Furthermore, RT-qPCR was conducted in the hypothalamus to analyse the same transcripts as shown in Fig
