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As such, investments in oral GLP-1s may generate value well beyond a single indication, laying the groundwork for a new generation of orally delivered biologics

Gnb2l1 : This guanine nucleotide binding protein (G protein), also known as Rack1 (receptor for activated protein kinase C 1), regulates intracellular Ca2+ levels, potentially contributing to processes such as learning, memory and synaptic plasticity by binding specifically to an ionotropic glutamate receptor and thereby dictating neuronal excitation and sensitivity [82]

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Exploratory analyses highlighted a link between treatment with tirzepatide and amelioration of biomarkers associated with inflammation and atherosclerotic cardiovascular diseases [84]

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