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Medicare Part D Gross Spending on GLP-1s Increased Five-Fold Between 2019 and 2024, But Estimated Rebates of Around 50% Mean That Net Spending is Much Lower Gross Medicare Part D spending on GLP-1s in 2024 (not accounting for rebates) totaled $27.5 billion, a five-fold increase from 2019, reflecting an expansion in use of GLP-1s with more recent FDA approvals for type 2 diabetes

The timing is particularly relevant as Americans face what public health experts describe as a perfect storm: record obesity rates colliding with economic constraints that make proven pharmaceutical interventions financially inaccessible to average consumers

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Compensated cirrhosis Patients with MASH-related compensated cirrhosis (Child-Pugh A) represent a clinically important subgroup given the risk of hepatic decompensation and HCC