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While activating both the GLP-1 and glucagon pathways is a well-known mechanism of action for its weight loss and anti-diabetic effects, Merck is instead trialing efinopegdutide primarily as a treatment for metabolic dysfunction-associated steatohepatitis (MASH)
In 2022, some of the top-selling drugs in this category were Novos Ozempic (US$ 8.7 billion), Lilly and partner Dainippon Sumitomos Trulicity (US$ 7.7 billion), Novos Victoza (US$ 1.8 billion), and Rybelsus (US$ 1.6 billion)
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The end result is more fat reduction and muscle growth than any single gold standard product, for less time and less money
We conclude that while pharmacy and medical benefits serve as distinct reimbursement channels, for patients they must work in concert
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