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1988 Jun;24(2):162-72

Choose Tirzepatide If: You want maximum weight loss results You have struggled with weight loss in the past The $150/month difference fits your budget You have significant weight to lose (50+ pounds) You want the medication with the best clinical trial outcomes Choose Semaglutide If: Budget is your primary concern Youre satisfied with 10-15% weight loss You want to try GLP-1 therapy at lower cost first You have less weight to lose (20-40 pounds) You can always switch to tirzepatide later if needed Many patients start with compounded semaglutide to test GLP-1 therapy at a lower cost, then switch to tirzepatide if they want enhanced results