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Besides, circRNA_09505 can promote AKT1 expression via regulating the IB/NF-B signaling pathway in macrophages, the most interesting is circRNA_09505 knockdown significantly alleviates arthritis and inflammation in CIA mice (278)
25(1): p
This unique characteristic provides flexibility in site selection
The safety profile is generally favorable, with most side effects being GI-related (nausea, constipation, diarrhea) that improve with time and gradual dose escalation
This reflects the enhanced efficacy achieved through combination therapy, allowing therapeutic goals to be reached at lower individual compound doses
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