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The sterol regulatory element-binding protein (SREBP) family of transcription factors plays a crucial role in lipid metabolism by regulating the expression of a series of enzymes required for lipid synthesis, and nuclear fragments of transcriptionally active SREBPs (nSREBPs) are unstable, degraded by the ubiquitin-proteasome pathway

None of those paths felt right

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veterans with type 2 diabetes and a pre-existing substance use disorder found that GLP-1 initiation was associated with roughly 40% lower risk of overdose compared to other diabetes medications