The small number of subjects analized in many studies could be below the sample size needed to give an information of both normal range in healthy subjects [25, 33, 34] and oxidative stress in psoriasis before and after treatments [21, 2527, 60]
However, in guidelines published in 2012, the British Columbia Medical Association (Canadian Ministry of Health) recommended a dose of 1000 g/day for pernicious anemia or food-bound cobalamin malabsorption [34]
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