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GLP-1 receptor agonist class data are instructive here
The findings havent resulted in a peer-reviewed scientific paper since they were posted in 2018, which is unusual and raises major questions
After placement on a magnetic stand to remove the buffer, samples were resuspended in antibody buffer (wash buffer with 0.02% digitonin and 2 mM EDTA) and incubated with the TRIM28 or AP2 antibody overnight at 4 C
A1c dropped by 0.29 percentage points vs just 0.06 with placebo ( P = .0012) and fasting plasma glucose by 6.6 mg/dL, while rising by 0.4 mg/dL in the placebo group ( P = .0012)
In the same study, patients were followed for an additional 12 weeks after the last dose of bimagrumab and experienced no weight regain
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