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Taken together, this also demonstrates that Fc-engineered human IgG variants with altered binding to FcRn behave differently in human and murine model systems, which highlights the importance of accounting for cross-species differences when studying Ab-based therapeutics and FcRn biology [101,102,103]
Barthel, F
PD involves biochemical changes that worsen neuronal degeneration, including -synuclein accumulation, dopaminergic neuron loss, and basal ganglia disruption
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