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Upon sensing environmental stress or cellular damage, the absent in melanoma 2 inflammasome (AIM2) and NLR family pyrin domain-containing 3 (NLRP3) inflammasome assemble and recruit the inflammasome adapter protein apoptosis-associated speck-like protein containing CARD, leading to the activation of pro-inflammatory caspases [137]

Considering the clinical application of serotonin signal activation for hair loss treatment, investigation of serotonin alternatives with lower off-target effects may be necessary

Whereas these concentrations were deliberately selected to represent environmentally relevant levels of Pb contamination commonly reported in polluted aquatic ecosystems and in water bodies impacted by industrial or agricultural effluents

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doi:10.1001/jamasurg.2015.1534 Coutinho M, Gerstein HC, Wang Y, Yusuf S