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A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP
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Using either a mast cell stabilizer or a medication to reduce prostaglandin E2 synthesis (e.g., a COX2 inhibitor) stopped the hypersensitivity in the animal model of IBS.[ref] In the Lifehacks section (below), youll find a more comprehensive list of substances that also trigger mast cell degranulation
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