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They are activated in the response to ROS and involved in the apoptotic response to oxidative stress

Differential Diagnosis Considered etiologies included: Primary psychiatric disorder Neuroinflammatory or neurodegenerative disease Endocrine dysfunction Chronic infection (Lyme disease, EBV) Chronic inflammatory response syndrome (CIRS) Environmental toxin exposure (including mycotoxins) The acute onset, lack of psychiatric history, and environmental correlation made a primary psychiatric etiology less likely

Adv Gerontol Uspekhi Gerontol 2021;34:107

10.3168/jds.2018-15639 142 KitajiriS.KatsunoT.SasakiH.ItoJ.FuruseM.TsukitaS