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Dose escalation should be dependent of patient side effect profile and gastrointestinal tolerability

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To avoid quick leakage from the delivery system, GOx is immobilized in copper phosphate mineralized particles to form hybrid nanoflowers (mineralized GOx, m-GOx), which are stable under various biological stimuli 39

fMRI=functional magnetic resonance imaging

"Obesity-related knee osteoarthritis is a progressive condition that can lead to pain and stiffness of the knee and impair critical daily functions such as walking or moving around," said lead researcher Dr