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Continued treatment and full discontinuation produce different outcomes
What scientific evidence supports its proposed use
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Clinical studies demonstrate that GLP-1 receptor activation reduces ghrelin levels by up to 20-30% in some patients, while simultaneously enhancing peptide YY (PYY) and cholecystokinin (CCK), both powerful satiety messengers
However, these GnRH antagonists are still associated with side effects including reduction in bone mineral density and risk of developing osteopenia and osteoporosis due to their induction of a hypoestrogenic state which limits their treatment regime duration (Rzewuska et al., 2023)
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