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Elimination After subcutaneous injection of TOUJEO in diabetic patients, insulin glargine is metabolized at the carboxyl terminus of the B-chain with formation of two active metabolites M1 (21 A -Gly-insulin) and M2 (21 A -Gly-des-30 B -Thr-insulin)

The robust 5 per cent from the SURMOUNT trials remains the most reliable figure

However, its crucial to remember that GLP-1 receptor agonists are not licensed for usage in non-diabetics, and there is limited information on their safety and effectiveness in this population

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