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Beyond its effects on the central nervous system, DSIP has been detected in peripheral organs, blood, cerebrospinal fluid, and even human breast milk, indicating a systemic physiological role

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6.2 Evidence for prebiotic use in Graves disease A beneficial role for prebiotics, in which some are indigestible oligosaccharides, soluble non-digestible fibers, indigestible sugars, but also anti- and honey drink cutaneous bacteria with the honey-producing lactobacilli and other lactobacilli, is evident by the overall protection offered [78]

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Unlike the first category, aptamers can directly and specifically bind to target proteins, functioning similarly to antibodies by providing a targeting mechanism

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