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Here we report cryo-EM structures of human OCTN2 in three conformations: inward-facing ligand-free, occluded carnitine- and Na + -bound, and inward-facing ipratropium-bound

Chronic low-grade inflammation is a common pathological feature of both: metabolic disturbances in patients with DM induce the release of peripheral inflammatory factors, and these inflammatory factors pass through the compromised BBB into the central nervous system (CNS), activating microglia and astrocytes and triggering a neuroinflammatory cascade response, which in turn promotes A deposition in AD and tau protein hyperphosphorylation (Sebastian Monasor et al., 2020

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In the later stages of wound repair, M2 polarization plays a critical role by producing anti-inflammatory, fibrogenic, and angiogenic mediators to limit local inflammation and promote tissue repair [43, 44]