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[5] Epithalon has demonstrated antioxidant activity in multiple preclinical models, with effects measurable as reductions in lipid peroxidation markers (malondialdehyde, 4-hydroxynonenal) and increases in endogenous antioxidant enzyme activity (superoxide dismutase, catalase, glutathione peroxidase)

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Cryo EM dynamics analysis and post-3D classification of CTR:Cagri/CagriBB complex 3D variability analysis (3DVA) implemented in cryoSPARC v4.4.1 29,39 was performed to interrogate and visualize the dynamics in the complexes as previously described 25