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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

Last reviewed: 1 August 2026

But medication alone isnt magic, its a powerful tool that works best when combined with comprehensive medical support, personalized guidance, and commitment to your health

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Additionally, these medications slow gastric emptying, which contributes to improved postprandial glucose control and promotes satiety, leading to reduced caloric intake and weight loss