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Tailoring a molecule to this specific purpose requires a substantial understanding of how the current class of GLP-1R agonists access and interact with the satiating and aversive neuronal receptor populations
However, GLP-1 has a very short half-life [5]
Additionally, participants who lost 10% body weight at any point during the study were classified as super high responders. Body weight, waist circumference, vital signs and body composition (measured using bioelectrical impedance analysis) were assessed at each visit
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