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1998 data Arginine co-administration / may augment GH release by suppressing somatostatin Melatonin / low-dose (0.5 to 1 mg) may potentiate nocturnal GH surge High-fat meals / free fatty acids suppress GH release for 2 to 4 hours Glucose load / 75 g oral glucose suppresses GH

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Because Retatrutide is still investigational, long-term safety especially outside controlled trials remains less certain