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In the univariate analysis, factors associated with improved NIRS data were l-carnitine administration (p = 0.0038) and baseline NIRS data (p = 0.0010) (Table 2)

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This does not diminish the therapeutic value of GLP-1 medications but instead underscores the importance of viewing weight loss through a broader physiological lens that accounts for body composition and long-term cardiometabolic health