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[1] [3] According to the UK SmPC, dosing starts at 2.5 mg once weekly for 4 weeks, then increases in 2.5 mg increments every 4 weeks until the target dose (5 mg, 7.5 mg, 10 mg, 12.5 mg or 15 mg) is reached, based on individual response and tolerability

There are virtually no adverse side effects

Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

A vial left out for two hours, returned to the fridge, then left out again for four hours has experienced six hours of cumulative exposure