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Developing and optimizing multi-target agonists could potentially address multiple aspects of metabolic disorders simultaneously
Retatrutide, a triple-receptor agonist still in Phase 3 clinical trials, has posted some of the most impressive weight loss numbers ever recorded in obesity research, hitting 24.2% body weight reduction in 48 weeks
Studies have shown that ROS can oxidize the cysteine residues in the amino acid transporter LAT1, which can affect its function and thus influence the entry of amino acids into cells [201, 202]
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