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Hay (Auckland) and Lutz (Zurich) are two key researchers in amylin biology
Follow-up appointments track gastrointestinal tolerance, metabolic changes, and safety markers every 4-8 weeks initially, then every 8-12 weeks
The multicenter, randomized, open-label SURMOUNT-5 trial evaluated the efficacy and safety of Lillys tirzepatide, marketed as Zepbound, and Novos semaglutide, marketed as Wegovy, in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea (OSA) or cardiovascular disease, who did not have diabetes
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The first human data on the combination are early but striking
