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The FDA also acknowledged that it lacks important information regarding any safety issues raised by MOTs-c, including whether it would cause harm if administered to humans. 5

Research Protocol Summary Study Protocol: 0.25 mg AOD-9604 administered intra-articularly via ultrasound guidance Frequency: Weekly injections Duration: 4-7 weeks in research studies Combination Therapy: 6 mg hyaluronic acid co-administered for enhanced effects Assessment Timeline: Significant improvements observed by 8-9 weeks Note: These protocols are from animal research and have not been validated for human use

Therefore, those patients benefitted from the supplementation of the vitamin B12

Subcutaneous (sub-Q) injects into the fat layer under the skin, leading to slower, more sustained absorption

It triggers an automatic denial on the drug line