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Additionally, upregulation of NOX2 has been shown to enhance the anti-pyroptotic and anti-inflammatory effects of metformin
Uncommon (110 in 1,000 people): acne-like breakouts, mild swelling, or increased sensitivity to sun
The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications
Other work flagged decorin, a small proteoglycan that doesnt bulk up collagen so much as govern how thick the collagen fibrils grow
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