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The specific NOX system of phagocytic cells is a multisubunit complex whose function is to generate reactive oxygen species (ROS) as a means to destroy invading pathogens
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This long-acting version is already circulating, unbound and highly available to cellular receptors throughout the body
35 for w GD + and 39 for UQCR-C1 GD +)
Of note, the role of -arrestins in GLP-1R trafficking is unclear, as loss of -arrestin-1 does not affect GLP-1R internalization 14,34
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