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5.2 Patient selection should be driven by complication burden, not BMI alone This shift has important implications for patient selection

Supporting Research and Data Context Recent studies reinforce the foundational science behind hydration, mineral intake, and nutrient signaling: Metabolism (2020): Found that berberine promotes AMPK activation, enhancing energy utilization

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Why Many Patients Interested in Future Therapies May Already Have Higher Health Risks It is important to recognise that many individuals researching emerging weight-management treatments may already have underlying risk factors such as: obesity or metabolic syndrome type 2 diabetes high blood pressure elevated cholesterol sleep apnoea These conditions increase cardiovascular risk independently of any treatment