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Subsequently, Yagoda and Yangs groups demonstrated that iron chelators could inhibit this type of cell death, discovered that Ras-selective lethal 3 (RSL3) mimicked Erastins effects in RAS-mutant cells, and found that elevated levels of ROS and iron were closely associated with RAS signaling (Yagoda et al., 2007

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Biomed Pharmacother 106:605609 Macedoni-Luki M, Gosar D, Bjrklund G, Oraem J, Kodri J, Lenik-Musek P, Zupani M, France-tiglic A et al (2015) Levels of metals in the blood and specific porphyrins in the urine in children with autism spectrum disorders

A double-blind study in chronic insomniac patients did not produce a clean confirmation of benefit (PMID 1299794), and other human work has treated the endogenous compound as a marker rather than a confirmed sleep agent