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UK patients should understand that: Available evidence is largely from Phase 2 studies with relatively short follow-up periods Long-term cardiovascular outcome data are not yet available for either agent Phase 3 trials are ongoing, and results will inform future regulatory submissions to the MHRA UK patients interested in accessing these treatments through clinical trials may wish to consult the NIHR 'Be Part of Research' portal (bepartofresearch.nihr.ac.uk) or ClinicalTrials.gov for current recruitment opportunities

How We Help You Manage Them: Hydration: We emphasize water intake and electrolytes

In Phase 3 trials, nausea affected up to 42.4% of people, diarrhoea up to 34.1%, constipation up to 26.1%, and vomiting up to 25.3%, depending on the dose

Focus on manufacturing oversight, quality assurance, dosing consistency, and available clinical evidence rather than assigning blame

Pediatr Res