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Metabolism of glutathione and a glutathione conjugate by isolated kidney cells

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We describe here a novel process utilizing reduced glutathione, further stabilized with punicalagins from pomegranate, delivered to the sublingual mucous membrane

Collectively, these findings highlight the critical role of SLC25A39-mediated mitochondrial glutathione import in preventing a localized, intra-mitochondrial oxidative crisis that directly initiates apoptotic cell death

Factors of glutathione deficiency include: Exposure to chemical toxins (including environmental pollution) UV radiation exposure Chronic stress Excessive alcohol use Smoking Poor diet Certain medications And we see the deficiency manifest as wrinkles, inflammation, hyperpigmentation and melasma