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LightForce Orthodontics, Burlington, MA

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GLP-1 Reduces appetite, slows gastric emptying GIP Enhances insulin, improves fat metabolism Glucagon Increases energy expenditure, burns fat Based on Phase 2 clinical trial data (published in NEJM, 2023), retatrutide's side effects are primarily gastrointestinal, similar to other GLP-1 agonists but with some differences due to the glucagon component

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Reported and theoretical concerns include injection-site reactions, dizziness or blood-pressure changes, and critically for compounds that promote angiogenesis a theoretical risk relating to tumor growth , since new blood vessels can also feed abnormal tissue

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